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KMID : 0381219810130010041
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Journal of RIMSK
1981 Volume.13 No. 1 p.41 ~ p.46
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A Study on the Change of Plasma Level of the Carbohydrate-Protein
Complex According to the Degree of Tissue Damage
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Lim Kun-Ho
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Abstract
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Biochemically the cell wall contains peripheral membrane protein and integral protein. And integral protein is essential elements of the cell wall as receptors for various antibodies, hormones and virus etc. and it could control the growth rate of the cell. And the transformed cells are deficit in amounts of fibronectin, one of most important integral protein in biologically and glycoprotein in chemically, and the degree of the deficiency of fibronectin of the cell wall is correlated with the degree of invasiveness of the transformed cells.
Variations in the plasma amounts of certain protein-carbohydrate complexs were reported. Soe et al reported increase in amounts protein-bound-carbohydrate and percentile of alpha-1 glycoprotein in the patients suffering from hepatoma. Wang et al reported increased amounts of plasma protein-bound-carbohydrate and percentile of alpha-1 glycoprotein in the suffering from typhoid fever, nonspecific inflammatory disease and malignant neoplasms.
Such reports indicate the possibilities of nonspefic increase in the amounts and/or percentile of the protein-carbohydrate complexes in the various disease groups causing tissue damage, but not the specific reaction which is correlated with the specific pathogenesis of the given disease entities.
In order to confirm such possibilities, the author collected 83 cases suffering various disease from August 1970 to August 1980, who were performed operation in the Dept. of Surgery, Choong-Ang University, Medical School and classified as mild, moderate and severe degree of tissue injury, and benign and malignant neoplasms according to its histopathologic findings.
Before the operation, the author collected plasma from each patients and estimated percentile of each glycoprotein fractions, seromucoid amounts of protein-bound-carbohydrate by the use of Helena´s zip zone electrophoresis kit for glycoprotein, Winzler´s method and phenol-sulfuric acid method.
The resulted conclusion was that the plasma level of the seromucoid was relatively correlated with the degree of tissue damage and increased in the patients suffering from malignant neoplasms.
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KEYWORD
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